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Báo cáo hóa học: " Accelerated Hydrolysis of Aspirin Using Alternating "
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Accelerated Hydrolysis of Aspirin Using Alternating | Nanoscale Res Lett 2009 4 854-857 DOI 10.1007 S11671-009-9332-8 NANO EXPRESS Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields Uwe M. Reinscheid Received 28 March 2009 Accepted 24 April 2009 Published online 7 May 2009 to the authors 2009 Abstract The major problem of current drug-based therapy is selectivity. As in other areas of science a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus which can be applied in a spatially and temporarily controlled manner. As a proof of principle the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 C was chosen. The sensor and actuator system is a commercially available gold nanoparticle NP suspension which is approved for animal usage stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution. Keywords Gold nanoparticle Magnetic field Relaxation Hydrolysis Pro-drug Introduction The biggest problem of drug-based therapy is selectivity because of side effects that can be dose-limiting. This challenge led to different strategies with chemically increased selectivity pro-drug approach and physically increased selectivity physical stimuli such as lasers 1 . The latter approach hyperthermia is used as sole agent or as an adjuvant therapy together with chemotherapy and radiotherapy 2 utilizing magnetic fields 3 and NIR lasers 4 . Despite promising results optical energy sources U. M. Reinscheid El Max-Planck-Institute for Biophysical Chemistry Am Fassberg 11 37077 Gottingen Germany e-mail urei@nmr.mpibpc.mpg.de are mainly limited to the treatment of subcutaneous tumours. As in other areas of science a combination of two effects might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field