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Báo cáo y học: "usceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors. | Open Access Research Susceptibility to glaucoma differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors Thomas J LukasH Haixi MiaoH Lin Chen Sean M Riordan Wenjun Li Andrea M Crabb Alexandria Wise Pan Du Simon M Lin and M Rosario Hernandez Addresses Department of Molecular Pharmacology and Biological Chemistry Feinberg School of Medicine Northwestern University E Chicago Ave Chicago IL 60611 USA. Department of Ophthalmology Feinberg School of Medicine Northwestern University E Chicago Ave Chicago IL 60611 USA. Department of Biology City College of New York Convent Ave New York NY 10031 USA. Robert H Lurie Comprehensive Cancer Center Feinberg School of Medicine Northwestern University E Chicago Ave Chicago IL 60611 USA. H These authors contributed equally to this work. Correspondence Thomas J Lukas. Email t-lukas@northwestern.edu Published 9 July 2008 Genome Biology 2008 9 R111 doi 10.1186 gb-2008-9-7-r1 11 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 7 R11 1 Received 9 May 2008 Revised 18 June 2008 Accepted 9 July 2008 2008 Lukas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Epidemiological and genetic studies indicate that ethnic genetic background plays an important role in susceptibility to primary open angle glaucoma POAG . POAG is more prevalent among the African-descent population compared to the Caucasian population. Damage in POAG occurs at the level of the optic nerve head ONH and is mediated by astrocytes. Here we investigated differences in gene expression in primary cultures of ONH astrocytes obtained from age-matched normal and glaucomatous donors of