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Báo cáo y học: "Ancient genomic architecture for mammalian olfactory receptor clusters"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Ancient genomic architecture for mammalian olfactory receptor clusters. | Open Access Research Ancient genomic architecture for mammalian olfactory receptor clusters Ronny Aloni Tsviya Olender and Doron Lancet Address Department of Molecular Genetics and the Crown Human Genome Center The Weizmann Institute of Science Rehovot 76100 Israel. Correspondence Doron Lancet. Email doron.lancet@weizmann.ac.il Published 01 October 2006 Received 14 August 2006 Genome Biology 2006 7 R88 doi l0.ll86 gb-2006-7-l 0-r88 Accepted I October 2006 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 10 R88 2006 Aloni et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mammalian olfactory receptor OR genes reside in numerous genomic clusters of up to several dozen genes. Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison aimed at reconstructing the ancestral olfactory subgenome. Results We developed a new and general tool for genome-wide definition of genomic gene clusters conserved in multiple species. Syntenic orthologs defined as gene pairs showing conservation of both genomic location and coding sequence were subjected to a graph theory algorithm for discovering CLICs clusters in conservation . When applied to ORs in five mammals including the marsupial opossum more than 90 of the OR genes were found within a framework of 48 multi-species CLICs invoking a general conservation of gene order and composition. A detailed analysis of individual CLICs revealed multiple differences among species interpretable through species-specific genomic rearrangements and reflecting complex mammalian evolutionary dynamics. One significant instance involves CLIC 1 which lacks a human member implying the .