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Báo cáo sinh học: " Lateral inhibition and concentration-invariant odor perception"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Lateral inhibition and concentration-invariant odor perception. | Journal of Biology BioMed Central Minireview Lateral inhibition and concentration-invariant odor perception Susy M Kim and Jing W Wang Address Section for Neurobiology Division of Biological Sciences University of California-San Diego 9500 Gilman Drive MC 0368 La Jolla CA 92093-0368 USA. Correspondence Jing W Wang. Email jw800@ucsd.edu Published 26 January 2009 Journal of Biology 2009 8 4 doi 10.1186 jbiol106 The electronic version of this article is the complete one and can be found online at http jbiol.com content 8 1 4 2009 BioMed Central Ltd Abstract Sensory identity usually remains constant across a large intensity range. Vertebrates use lateral inhibition to match the sensitivity of retinal ganglion cells to the intensity of light. A new study published in Journal of Biology suggests that lateral inhibition in the Drosophila antennal lobe is similarly required for concentration-invariant perception of odors. Adaptation is a fundamental neural mechanism for stable sensory perception in a changing environment. For example our perception of the contrast between the black text and the white background of a page remains constant under a variety of illumination conditions ranging from indoor lighting to bright sunlight. In a manner similar to this the olfactory system must be able to perceive the same odor identity across a wide range of concentrations. Why might this be important To navigate towards an odor source a Drosophila larva must be able to recognize odor intensity as well as concentrationinvariant odor identity. From physiological studies however we know that the odor response of odorant receptor neurons ORNs normally saturates within one or two orders of magnitude 1 . In addition the number of ORNs activated by an odor increases with odor concentration -thus creating a shifting odor representation in the antennal lobe. Despite this Drosophila larvae can navigate towards an attractive odor source across a much broader range of odor concentrations 2 . How