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Báo cáo sinh học: " Quantitative genetics of taura syndrome resistance in pacific white shrimp (penaeus vannamei): a cure model approach"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Quantitative genetics of taura syndrome resistance in pacific white shrimp (penaeus vannamei): a cure model approach | 0degảrd et al. Genetics Selection Evolution 2011 43 14 http www.gsejournal.Org content 43 1 14 GSE Ge n et i cs Selection Evolution RESEARCH Open Access Quantitative genetics of taura syndrome resistance in pacific white shrimp penaeus vannamei a cure model approach 1.2 34 5 2 3 1.2 J0rgen 0degard Thomas Gitterle Per Madsen Theo HE Meuwissen M Hossein Yazdi Bjarne Gjerde Carlos Pulgarin4 and Morten Rye3 Abstract Background In aquaculture breeding resistance against infectious diseases is commonly assessed as time until death under exposure to a pathogen. For some diseases a fraction of the individuals may appear as cured non-susceptible and the resulting survival time may thus be a result of two confounded underlying traits i.e. endurance individual hazard and susceptibility whether at risk or not which may be accounted for by fitting a cure survival model. We applied a cure model to survival data of Pacific white shrimp Penaeus vannamei challenged with the Taura syndrome virus which is one of the major pathogens of Panaeid shrimp species. Methods In total 15 261 individuals of 513 full-sib families from three generations were challenge-tested in 21 separate tests tanks . All challenge-tests were run until mortality naturally ceased. Time-until-event data were analyzed with a mixed cure survival model using Gibbs sampling treating susceptibility and endurance as separate genetic traits. Results Overall mortality at the end of test was 28 while 38 of the population was considered susceptible to the disease. The estimated underlying heritability was high for susceptibility 0.41 0.07 but low for endurance 0.07 0.03 . Furthermore endurance and susceptibility were distinct genetic traits rg 0.22 0.25 . Estimated breeding values for endurance and susceptibility were only moderately correlated 0.50 while estimated breeding values from classical models for analysis of challenge-test survival ignoring the cured fraction were closely correlated with estimated breeding values