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Atlas of Human Pluripotent Stem Cells

Human embryonic stem cell (hESC) lines, like those from other species, are pluripotent cell lines derived from the inner cell mass (ICM) of the developing embryo. Due to their exceptional capability of proliferating indefi nitely as undifferentiated cells when cultured in appropriate conditions, and of sustaining a normal karyotype, hESCs may have broad applications for industrial uses; clinical purposes, namely, cell-based therapy; and research of early human development, differentiation mechanisms, and lineage commitment. The fi rst ESC lines were derived from mouse embryos in 1981 (Evans and Kaufman 1981 ; Martin 1981 ) . Bongso and colleagues later demonstrated that ESC-like cells can be isolated from human embryos. They. | Stem Cell Biology and Regenerative Medicine Michal Amit Joseph Itskovitz-Eldor Editors Atlas of Human Pluripotent Stem Cells Derivation and Culturing Humana Press Stem Cell Biology and Regenerative Medicine Series Editor Kursad Turksen Ph.D. kturksen@ohri.ca For further volumes http www.springer.com series .