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Báo cáo y học: "Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status. | Research Open Access Systems biology-defined NF-xB regulons interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status Bin YanH Guang ChenHn Kunal Saigal Xinping Yang Shane T Jensen Carter Van Waes Christian J Stoeckert and Zhong Chen Addresses Head and Neck Surgery Branch NIDCD National Institutes of Health Bethesda MD 20892 USA. Department of Bioengineering Smith Walk University of Pennsylvania Philadelphia Pennsylvania 19104 USA. Center for Bioinformatics Guardian Drive University of Pennsylvania Philadelphia Pennsylvania 19104 USA. NIH-Pfizer Clinical Research Training Program Award University of Pennsylvania Philadelphia Pennsylvania 19104 USA. Department of Statistics The Wharton School Walnut Street University of Pennsylvania Philadelphia Pennsylvania 19104 USA. Department of Genetics School of Medicine Curie Boulevard University of Pennsylvania Philadelphia Pennsylvania 19104 USA. H These authors contributed equally to this work. Correspondence Zhong Chen. Email chenz@nidcd.nih.gov Published II March 2008 Received 8 November 2007 Genome Biology 2008 9 R53 doi 10.1 186 gb-2008-9-3-r53 ReVLSeL28 anuary.2-008 gy g Accepted II March 2008 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 3 R53 2008 Yan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Aberrant activation of the nuclear factor kappaB NF-xB pathway has been previously implicated as a crucial signal promoting tumorigenesis. However how NF-xB acts as a key regulatory node to modulate global gene expression and contributes to the malignant heterogeneity of head and neck cancer is not well