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COLORECTAL CANCER BIOLOGY – FROM GENES TO TUMOR

Clinical course of CLL is variable. Recently, progress has been made in the identification of biological markers that could predict disease progression. Particularly, the expression of unmutated Ig genes, some cytogenetic abnormalities like 17p and 11q deletions and the expression of the zeta-associated protein 70 (ZAP-70) are associated to a poor prognosis. A major scientific goal is to find a biomolecular explanation for CLL prognosis heterogeneity that can provide clues in the understanding of disease etiology and pathogenic mechanisms which favor the onset of the disease, as well as its progression and evolution into aggressive variants (Richter’s lymphoma or. | COLORECTAL CANCER BIOLOGY -FROM GENES TO TUMOR Edited by Rajunor Ettarh INTECHWEB.ORG Colorectal Cancer Biology - From Genes to Tumor Edited by Rajunor Ettarh Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Tajana Jevtic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Colorectal Cancer Biology - From Genes to Tumor Edited by Rajunor Ettarh p. cm. 978-953-51-0062-1 INTECH open science I open minds free online editions of .