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Báo cáo y học: " Volume of the effect compartment in simulations of neuromuscular block"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Volume of the effect compartment in simulations of neuromuscular block | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Volume of the effect compartment in simulations of neuromuscular block Vladimir Nigrovic 1 Johannes H Proost2 Anton Amann3 and Shashi B Bhatt1 Address Department of Anesthesiology Medical University of Ohio Toledo OH USA 2Research Group for Experimental Anesthesiology and Clinical Pharmacology University Hospital Groningen Groningen The Netherlands and 3Department of Anesthesiology and Critical Care Medicine Leopold-Franzens University Innsbruck Austria and Department of Environmental Sciences The Swiss Federal Institute ofTechnology Zurich Switzerland Email Vladimir Nigrovic - vnigrovic@meduohio.edu Johannes H Proost - j.h.proost@rug.nl Anton Amann - Anton.Amann@uibk.ac.at Shashi B Bhatt - sbhatt@meduohio.edu Corresponding author Published 03 October 2005 Received 02 September 2005 Theoretical Biology and Medical Modelling 2005 2 41 doi 10.1186 1742-4682-2-41 Accepted 03 October 2005 This article is available from http www.tbiomed.cOm content 2 1 41 2005 Nigrovic et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The study examines the role of the volume of the effect compartment in simulations of neuromuscular block NMB produced by nondepolarizing muscle relaxants. Methods The molar amount of the postsynaptic receptors at the motor end plates in muscle was assumed constant the apparent receptor concentration in the effect compartment is the ratio of this amount and the volume arbitrarily assigned to the effect compartment. The muscle relaxants were postulated to diffuse between the central and the effect compartment and to bind to the postsynaptic receptors. NMB was calculated from the free concentration of the muscle .