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Báo cáo y học: "Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study. | Child and Adolescent Psychiatry and Mental Health BioMed Central Research Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents case-control study William C Jangro Horacio Preval Robert Southard Steven G Klotz and Andrew Francis Open Access Address Dept. Psychiatry Behavioral Sciences SUNY at Stony Brook Stony Brook NY 11794 USA Email William C Jangro - william.jangro@sunysb.edu Horacio Preval - hppsychdoc@aol.com Robert Southard - robert.southard@sunysb.edu Steven G Klotz - stevenklotz@gmail.com Andrew Francis - andrew.francis@sunysb.edu Corresponding author Published 12 March 2009 Received 23 October 2008 Child and Adolescent Psychiatry and Mental Health 2009 3 9 doi 10.1186 1753-2000-3-9 Accepted 12 March 2009 This article is available from http www.capmh.cOm content 3 1 9 2009 Jangro et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Objective The objective of this study was to compare intramuscular IM ziprasidone to conventional IM medications haloperidol combined with lorazepam for the treatment of severe agitation in adolescents age 12-17 . Methods We retrospectively identified consecutive severe agitation episodes defined as requiring physical restraint in adolescents treated with either IM ziprasidone or conventional IM agents in a psychiatric emergency room. For ziprasidone the dosage was 20 mg for 23 episodes and 10 mg for 5 episodes. For 24 episodes treated with combined haloperidol and lorazepam the dosages were 4.8 0.3 SEM mg and 1.9 0.4 mg respectively. Outcomes were the duration of restraint and need for adjunctive rescue medications within 60 minutes. These outcomes were decided prior to reviewing any records. Results No difference was found in restraint .