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báo cáo khoa học: " Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines | Head Face Medicine BioMed Central Open Access Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines Urs DA Muller-Richter 1 Albert Dowejko2 Tobias Reuther1 Johannes Kleinheinz3 Torsten E Reichert2 and Oliver Driemel2 Address 1Dpt of Oral and Maxillofacial Plastic Surgery University Hospital Wurzburg Pleicherwall 2 97070 Wurzburg Germany 2Dpt of Oral and Maxillofacial Surgery University Hospital Regensburg Franz-Josef-Strauss-Allee 11 93053 Regensburg Germany and 3Dpt of Maxillofacial Surgery University of Munster Waldeyerstrafie 30 48149 Munster Germany Email Urs DA Muller-Richter - mueller_u2@klinik.uni-wuerzburg.de Albert Dowejko - albert.dowejko@klinik.uni-regensburg.de Tobias Reuther - reuther_t@klinik.uni-wuerzburg.de Johannes Kleinheinz - joklein@uni-muenster.de Torsten E Reichert - torsten.reichert@klinik.uni-regensburg.de Oliver Driemel - oliver.driemel@klinik.uni-regensburg.de Corresponding author Published 9 April 2009 Received 31 July 2008 Head Face Medicine 2009 5 10 doi 10.1186 1746-160X-5-10 Accepted 9 April 2009 This article is available from http www.head-face-med.eom content 5 1 10 2009 Muller-Richter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The immunological response to solid tumours is insufficient. Therefore tumour specific antigens have been explored to facilitate the activation of the immune system. The cancer testis antigen class of MAGE-A antigens is a possible target for vaccination. Their differential expression profiles also modulate the course of the cancer disease and its response to antineoplastic drugs. Methods The expression profiles of MAGE-A2 -A3 -A4 -A6 and -A10 in five own oral squamous cell carcinoma cell lines were