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Báo cáo y học: "Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways. | Saw et al. Chinese Medicine 2010 5 37 http www.cmjournal.Org content 5 1 37 CHINESE MEDICINE REVIEW Open Access Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 NFE2L2 anti-oxidative stress anti-inflammatory pathways Constance Lay-Lay Saw1 2 Qing Wu1 2 3 Ah-Ng Tony Kong1 2 Abstract This article reviews recent basic and clinical studies of ginseng particularly the anti-cancer effects and the potential chemopreventive actions by activating the transcriptional factor nuclear factor erythroid-derived 2 -like 2 Nrf2 or NFE2L2 -mediated anti-oxidative stress or anti-inflammatory pathways. Nrf2 is a novel target for cancer prevention as it regulates the antioxidant responsive element ARE a critical regulatory element in the promoter region of genes encoding cellular phase II detoxifying and anti-oxidative stress enzymes. The studies on the chemopreventive effects of ginseng or its components products showed that Nrf2 could also be a target for ginseng s actions. A number of papers also demonstrated the anti-inflammatory effects of ginseng. Targeting Nrf2 pathway is a novel approach to the investigation of ginseng s cancer chemopreventive actions including some oxidative stress and inflammatory conditions responsible for the initiation promotion and progression of carcinogenesis. Background Ginseng protects the cardiovascular system stimulates the central nervous system 1 and possesses anti-cancer activities 2 3 inhibiting human gastric adenocarcinoma 4 and human breast carcinoma 5 . Therefore ginseng is a potential cancer preventive agent 6 . Nuclear factor erythroid-derived 2 -like 2 Nrf2 or NFE2L2 is a key regulator of the antioxidant responsive element ARE -mediated gene expression and therefore a potential anti-cancer target for chemopreventive compounds 7 including ginseng 8-10 . However concerns have been raised for possible inappropriate claims of ginseng products 11 12 . This article reviews the potential chemopreventive actions of .