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Báo cáo y học: "rug discovery from Chinese medicine against neurodegeneration in Alzheimer’s and vascular dementia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: rug discovery from Chinese medicine against neurodegeneration in Alzheimer’s and vascular dementia. | Ho et al. Chinese Medicine 2011 6 15 http www.cmjournal.Org content 6 1 15 CHINESE MEDICINE REVIEW Open Access Drug discovery from Chinese medicine against neurodegeneration in Alzheimer s and vascular dementia Yuen-Shan Ho1 Kwok-Fai So1 2 3 and Raymond Chuen-Chung Chang1 2 3 Abstract Alzheimer s disease and vascular dementia are two major diseases associated with dementia which is common among the elderly. While the etiology of dementia is multi-factorial and complex neurodegeneration may be the major cause of these two diseases. Effective drugs for treating dementia are still to be discovered. Current western pharmacological approaches against neurodegeneration in dementia develop symptom-relieving and diseasemodifying drugs. Current integrative and holistic approaches of Chinese medicine to discovering drugs for neurodegeneration in dementia include 1 single molecules from the herbs 2 standardized extracts from a single herb and 3 herbal formula with definite composition. This article not only reviews the concept of dementia in western medicine and Chinese medicine but also evaluates the advantages and disadvantages of these approaches. Introduction Alzheimer s disease AD and vascular dementia VaD are the major forms of dementia. In addition in the postmortem brains of the late stage of Parkinson s dis-ease Lewy body disease also find pathological hallmarks of AD 1 . Senile dementia is the progressive decline of memory and some related cognitive functions in the elderly. The global dementia population is predicted to reach 81.1 million by 2040 2 . In 2010 the estimated prevalence of senile dementia in China is 6.0 to 7.0 million accounting for about one-sixth of the global prevalence the prevalence is expected to increase to 22.5 million by 2040 accounting for one-fourth of the global prevalence by that time 3 . The rapid increase in the number of dementia patients urgently demands effective prevention and treatment. Current approaches to dementia-related .