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Báo cáo y học: " Low autocrine interferon beta production as a gene therapy approach for AIDS: Infusion of interferon beta-engineered lymphocytes in macaques chronically infected with SIVmac251"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Low autocrine interferon beta production as a gene therapy approach for AIDS: Infusion of interferon beta-engineered lymphocytes in macaques chronically infected with SIVmac251 | BioMed Central Retrovirology Research Open Access Low autocrine interferon beta production as a gene therapy approach for AIDS Infusion of interferon beta-engineered lymphocytes in macaques chronically infected with SIVmac251 Wilfried Gay1 Evelyne Lauret2 Bertrand Boson1 Jerome Larghero2 Franck Matheux1 Sophie Peyramaure2 Véronique Rousseau3 Dominique Dormont1 Edward De Maeyer2 and Roger Le Grand 1 Address 1CEA Laboratoire d Immuno-Pathologie Expérimentale Service de Neurovirologie CRSSA EPHE IPSC Université Paris XI 18 route du Panorama 92265 Fontenay aux Roses Cedex France 2INSERM U362 Institut Gustave Roussy 39 rue Camille Desmoulins 94805 Villejuif France and 3Institut Fédératif de Neurobiologie Alfred Fessard CNRS UPR 9040 91198 Gif-sur-Yvette cedex France Email Wilfried Gay - WGAYLEN@aol.com Evelyne Lauret - elauret@igr.fr Bertrand Boson - Bertrand.Boson@ens-lyon.fr Jérome Larghero - j.larghero@chu-stlouis.fr Franck Matheux - matheux9@etu.unige.ch Sophie Peyramaure - peyramas@guerbet-group.com Véronique Rousseau - Veronique.Rousseau@nbcm.cnrs-gif.fr Dominique Dormont - legrand@dsvidf.cea.fr Edward De Maeyer - elauret@igr.fr Roger Le Grand - legrand@dsvidf.cea.fr Corresponding author Published 25 September 2004 Received 03 September 2004 Accepted 25 September 2004 Retrovirology 2004 1 29 doi l0.ll86 l 742-4690-1-29 This article is available from http www.retrovirology.cOm content 1 1 29 2004 Gay et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The aim of this study was to evaluate gene therapy for AIDS based on the transduction of circulating lymphocytes with a retroviral vector giving low levels of constitutive macaque interferon p production in macaques chronically infected with a pathogenic

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