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Addition of Pullulan to Trehalose Glasses Improves the Stability of βGalactosidase at High Moisture Conditions
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Incorporation of therapeutic proteins in a matrix of sugar glass is known to enhance protein stability, yet protection is often lost when exposed to high relative humidity (RH). We hypothesized that especially in these conditions the use of binary glasses of a polysaccharide and disaccharide might yield advantages for protein stability. |