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Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: A study protocol for an open-label phase I/ II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma

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Cancer-associated fibroblasts (CAFs) are an important component of the tumour microenvironment. Recent studies revealed CAFs are heterogeneous and CAF subset(s) that suppress cancer progression (cancerrestraining CAFs [rCAFs]) must exist in addition to well-characterised cancer-promoting CAFs (pCAFs). |

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