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Prognostic effect of lncRNA SNHG7 on cancer outcome: A meta and bioinformatic analysis

New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occurrence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in various kinds of tumors. However, the small sample size was the limitation for the prognostic value of SNHG7 in clinical application. | Zhang et al. BMC Cancer 2022 22 10 https doi.org 10.1186 s12885-021-09068-w RESEARCH Open Access Prognostic effect of lncRNA SNHG7 on cancer outcome a meta and bioinformatic analysis Yunyuan Zhang1 Qingwu Tian1 Shifeng Huang2 Qing Wang1 Hongmei Wu3 Qian Dong4 5 6 and Xian Chen1 Abstract Background New evidence from clinical and fundamental researches suggests that SNHG7 is involved in the occur- rence and development of carcinomas. And the increased levels of SNHG7 are associated with poor prognosis in vari- ous kinds of tumors. However the small sample size was the limitation for the prognostic value of SNHG7 in clinical application. The aim of the present meta-analysis was to conduct a qualitative analysis to explore the prognostic value of SNHG7 in various cancers. Methods Articles related to the SNHG7 as a prognostic biomarker for cancer patients were comprehensive searched in several electronic databases. The enrolled articles were qualified via the preferred reporting items for systematic reviews and meta-analysis of observational studies in epidemiology checklists. Additionally an online database based on The Cancer Genome Atlas TCGA was further used to validate our results. Results We analyzed 2418 cancer patients that met the specified criteria. The present research indicated that an elevated SNHG7 expression level was significantly associated with unfavorable overall survival OS HR 2.45 95 CI 2.12 2.85 p Zhang et al. BMC Cancer 2022 22 10 Page 2 of 13 Keywords Cancer SNHG7 meta-analysis prognostic biomarker Background tumors. However the small sample size was the limita- With the increasing prevalence of cancer carcinomas had tion for the prognostic value of SNHG7 in clinical appli- gradually been recognized as a major threaten to human cation. In the present study a qualitative meta-analysis health the world over 1 2 . Although great progresses was conducted to explore the prognostic effect of SNHG7 continued to be made in cancer treatment it is not .