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Comparative study between the effects of some dietary sources and metformin drug on weight reduction in obese rats

The research aimed at comparative study between brown rice, germinated brown rice, and oat and metformin on overweight reduction in obese rats of lipid profiles (total cholesterol, triglycerides, low density lipoprotein (LDL-c), high density lipoprotein (HDL-c) and very low density lipoprotein (VLDL-c)) and liver function (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) in rats. | Annals of Agricultural Science 2015 60 2 381 388 H O S T E D BY Faculty of Agriculture Ain Shams University Annals of Agricultural Science www.elsevier.com locate aoas Comparative study between the effects of some dietary sources and metformin drug on weight reduction in obese rats Zenab M. Mosa a Y.A. El Badry a Hala S. Fattah b Eman G. Mohamed a a Nutrition and Food Sciences Home Economics Dept. Fac. of Specific Education Ain-Shams University Egypt b Biochemistry and Nutrition Dept. Fac. of Women Ain-Shams University Egypt Received 18 October 2015 accepted 2 November 2015 Available online 30 December 2015 KEYWORDS Abstract The worldwide obesity epidemic has produced profound effects on public health. Grain Obesity such as rice and oat may offer some protection against the early stage of obesity and the develop- Brown rice ment of complications. The research aimed at comparative study between brown rice germinated Oat brown rice and oat and metformin on overweight reduction in obese rats of lipid profiles total Metformin cholesterol triglycerides low density lipoprotein LDL-c high density lipoprotein HDL-c and Lipid profiles very low density lipoprotein VLDL-c and liver function Aspartate Aminotransferase AST Liver function and Alanine Aminotransferase ALT in rats. This work was carried out on 60 adult male white albino rats Sprague-Dawley strain randomly classified into ten groups. The results indicate that the statistical analysis referred that the positive control group was significantly increased in feed intake triglycerides HDL LDL-cholesterol and VLDL-cholesterol comparing with group 3 188.43 g and 98 g 123.8 mg dL and 117.3 mg dL 5.42 mg dL and 0.439 mg dL 24.767 mg dL and 23.467 mg dL . On the other hand group 6 in the relative weight heart kidney and liver was significantly decreased comparing with positive control group 0.417 g and 0.517 g 0.8 g and 1.15 g 3.51 g and 5.65 g . Data represented showed that the significant increase in positive control .