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Synthesis and antimicrobial and antioxidant activities of hybrid molecules containing benzotriazole and 1,2,4-triazole

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Eleven novel 1,2,4-triazolylbenzotriazoles have been prepared using 1-(hydrazinylcarbonylmethyl)-1H -benzotriazole (3) as a potent intermediate. Compound 3, however, was obtained from benzotriazole in two steps. All synthesized compounds were characterized by detailed spectral studies like IR, 1 H NMR, 13 C NMR, and mass spectrometry. All synthesized compounds were evaluated for their in vitro antimicrobial activity against seven strains of bacteria and four strains of fungi. Compounds 13, 17, 19, 20, and 21 were found to possess antibacterial activity comparable to that of ciprofloxacin against a Klebsiella pneumoniae strain. |