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Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by singleembryo RNA sequencing

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Nuclear reprogramming reinstates totipotency or pluripotency in somatic cells by changing their gene transcription profile. This technology is widely used in medicine, animal husbandry and other industries. However, certain deficiencies severely restrict the applications of this technology |

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Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by singleembryo RNA sequencing

Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure