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Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs

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Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus to one round which is insufficient to cause the disease. |

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Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs

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