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Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

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The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunoglobulin gene-MYC fusion are the crucial initiating oncogenic events. |

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