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GMP-grade α-TEA lysine salt: A 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

Alpha-tocopheryloxyacetic acid (α-TEA) is a semi-synthetic derivative of naturally occurring vitamin E (alpha-tocopherol) that can be delivered via an oral route. Preclinical in vitro and in vivo data demonstrated that α-TEA is a potent anti-tumor agent with a safe toxicity profile in mice. |