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Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells

P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Posttranslational protein modification abnormalities have been confirmed to be an important mechanism underlying inactivation of p53. | Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells