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Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the United States. High-throughput genotyping has enabled discovery of germline genetic susceptibility variants (herein referred to as germline mutations) associated with an increased risk of developing PCa. | Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer