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C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells

Tamoxifen is a frontline therapy for estrogen receptor (ER)-positive breast cancer in premenopausal women. However, many patients develop resistance to tamoxifen, and the mechanism underlying tamoxifen resistance is not well understood. | C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells