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High-dose thiotepa-related neurotoxicity and the role of tramadol in children

Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. | High-dose thiotepa-related neurotoxicity and the role of tramadol in children