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Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade

Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested. | Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade