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A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells

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Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. | A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation melanoma cell invasion and drug-induced selection of ABCB5-expressing cells