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Low-dose evans blue dye for near-infrared fluorescence imaging in photothrombotic stroke model

Evans blue dye (EBD) is the most common indicator to analyze the extent of blood-brain barrier (BBB) breakdown in several neurological disease models. However, the high-dose of EBD (51.9 mg/kg) is usually required for visualization of blue color by the human eye that brings potential safety issues. | Low-dose evans blue dye for near-infrared fluorescence imaging in photothrombotic stroke model