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Study the application of public cord blood stem cell transplantation for Leukemia treatment (from 10-2016 to 9-2018)

To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. | Journal of military pharmaco-medicine no1-2019 STUDY THE APPLICATION OF PUBLIC CORD BLOOD STEM CELL TRANSPLANTATION FOR LEUKEMIA TREATMENT (FROM 10 - 2016 TO 9 - 2018) Bach Quoc Khanh1; Tran Ngoc Que1; Nguyen Ba Khanh1,2; Vo Thi Thanh Binh1 Dang Thi Thu Hang2; Nguyen Vu Bao Anh1,2; Nguyen Tuan Tung3 Kieu Thi Van Oanh3; Vu Duy Hong1; Duong Quoc Chinh1 Hoang Thi Thanh Nga1; Nguyen Anh Tri1 SUMMARY Objectives: To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. Subjects and method: Interventional, retrospective and prospective study. Subjects included 3,466 public cord blood units which were successfully stored, 05 patients with acute leukemia, transplanted by cord blood stem cell, in National Institute of Hematology and Blood Transfusion, from October of 2016 to September of 2018. Results: After 02 years of following up, among 3,466 stored public cord blood units, the 7 5 mean total nucleated cell was 130.4 ± 41.9 x 10 , the mean CD34 cell was 45.9 ± 35.5 x 10 , the post-thawed viability of stem cells was 84.7 ± 3.4%; there were 30 acute leukemia patients who were indicated for stem cell searching in public cord blood bank and the rate of successful search was 97.7%; 05 patients were transplanted using the matched stem cell units; among that, 02 patients achieved stable engraftment; the most common complications were mucosal ulceration (100%), bacteremia (100%) and CMV reactivation (100%); graft versus host disease happened in 01 case; 03 mortality cases were all due to severe sepsis. Conclusion: Allogeneic cord blood transplantation is a promising and effective method for the treatment of acute leukemia. * Keywords: Acute leukemia; Allogeneic; Stem cell transplantation; Cord blood; Stem cell. INTRODUCTION Acute leukemia is one of the most malignant hematological diseases with very high mortality .